CalciMedica is focused on the discovery and development of novel drugs for the treatment of acute and chronic inflammatory and immune disorders, and organ transplant rejection.
The Company’s strategy is based on the specific inhibition of the calcium release-activated calcium (CRAC) channel, a key component of the Icrac pathway in immune cells. In most other cell types, CRAC channels are involved in maintaining general calcium homeostasis, and in some situations dysfunction of this process can lead to disease. In immune cells, however, the Icrac pathway is essential for the adaptive immune response, and has been validated as a drug target in immune disease in humans. CRAC channels have also been found to play a key role in other inflammatory diseases, such as acute pancreatitis, which the Company is currently pursuing.